Injecting three hormones under the skin causes weight loss in the obese

During some experiments, researchers at Imperial College London noticed a reduction in body weight and glucose levels in obese patients with diabetes in about four weeks. The reduction took place thanks to the injection of a particular mix of hormones.

According to researchers at Imperial College, the procedure known as “gastric bypass,” sometimes very effective for reducing excess weight, is efficient because it causes a greater production of three specific hormones by the cells of the small intestine and colon.

It is a combination of hormones called “GOP” which reduces appetite and causes a loss of weight, also improving the body’s ability to use absorbed sugar in foods, which is very important for diabetics.

Based on this notion, the researchers injected a mix of three hormones into patients: peptide 1 similar to glucagon (GLP-1), oxintomodulin (OXM) and peptide YY (PYY). This combination mimicked the combination of hormones whose increased production occurs after the aforementioned surgery.

Patients received this treatment for four weeks. The injection took place through a special pump that slowly introduced the mix into the body, under the skin, for 12 hours a day. At the same time, patients followed a diet prescribed by a dietitian.

According to Tricia Tan, a professor at Imperial College and the lead author of the study, the results have shown promise and show significant improvements in patient health in just four weeks. The same researcher in the press release adds: “Compared to other methods the treatment is non-invasive and has reduced glucose levels to almost normal levels in our patients.”

The results of the study were published in Diabetes Care.

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