Mini human liver created in the laboratory to simulate diseases and study them

Miniature cultured human liver labs were created by a group of researchers from the University of Pittsburgh School of Medicine. The “mini livers” could help to simulate the progressions of various liver diseases and therefore to test their therapies.

The researchers transformed genetically modified human skin cells into 3D liver tissue in “stripped” mouse livers of their own cells. Real functional 3D mini livers have therefore blossomed in the laboratory with lots of blood vessels and structural features of a normal human liver.

Researchers have already managed to mimic in particular non-alcoholic fatty liver disease. This condition sees the accumulation of fatty parts in the liver, a condition which in turn leads to very serious diseases such as cirrhosis or liver failure.

This is the first time that genetically modified human “mini livers” are created, as recalled by Alejandro Soto-Gutierrez, professor of pathology in Pittsburgh and senior author of the study. This is an important result because very often the experiments that are carried out on animals, mainly on mice, even if promising, do not turn out to be effective in clinical studies on humans.

This is because, of course, “mice are not human,” as Soto-Gutierrez himself recalls. There are some important differences between us and them, including mutations that predispose us to specific diseases, which is not possible to study in mice.

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